Colistimethate Sodium (Sterile) IP 4.5 Million IU.
- Injection:
The normal adult dose should be dissolved in 10 ml of sterile water for injections to form a clear solution and given over a minimum of 5 minutes.
The solution is for single use only and any remaining solution should be discarded.
Swirl gently during reconstitution to avoid frothing.
- Infusion:
Colistimethate Sodium can be given as a 50 ml intravenous infusion in 0.9% sodium chloride solution a minimum of 5 days treatment is generally recommended. For the treatment of respiratory or sterile water for injections.
Exacerbations in cystic fibrosis patients, treatment should be continued for up to 12 days.
| Normal Renal Function
| - 3 million IU (240 mg CMS) Every 8h
|
| Renal Failure |
- For serum creatinine level 1.3-1.5 mg/dl, 16-2.5 mg/dl, or ≥ 2.6 mg/dl, the recommended dosage of intravenous colistin is 2 million IU (160 mg CMS) every 8h, 12h, or 24h, respectively
|
| Renal Replacement Therapy |
- 2 million IU (160 mg CMS) after each hemodialysis
- 2 million IU (160 mg CMS) daily during peritoneal dialysis
|
Route of Administration:
IV/IM
