• The usual Piperacillin Tazobactam adult dose is 4.5 g (Piperacillin 4g/ Tazobactam 0.5g) given every 8 hours totalling 13.5 g(12g Piperacillin Sodium/ 1.5 g Tazobactam Sodium).
• In patients with renal insufficiency, the following dosage schedule is recommended.

Creatinine clearance(ml/min)	Recommended Dosage regimen
>40-90	3.375g every 6 hrs.
20-40	2.250g every 6 hrs
20	2.250g every 8 hrs

Route of Administration:

IV/IM

• Reconstitute initially (2.25 g in 10 mL, 4.5 g in 20 mL) with water for injections, or glucose 5%, or sodium chloride 0.9%, then dilute to 50–150 mL with infusion fluid; give over 30 minutes.