Imipol-1gm

  • Maintains its efficacy( >90%)against gram-negative bacilli,inclding ESBL-producing isolates,for the treatment of intra-abdominal infections as against the comparators.
  • Better response rates (90 VS 76%) compared to piperacillin/tazobactam in febrile neutropenic patients.
  • A 2 hour of 1 gm imipenem every 6 hours maintains serum concentrations above 4 X MIC (4 mg/L) for more than 40% of the dosing interval.
  • Achieves high peak plasma concentrations rapidly in critically ill patients.
  • When used in combination with colistin,improved the survival in K.pneumoniae carbapenama(KPC) bacteraemic patients.
  • 1 gm dosing every 6 hours is safe and well tolerated.