Category
sulbactam: Beta-lactamase inhibitors
sulbactam is a beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections.
Storage :
- Before Opening
Store below 25°C. Protect from light.
- Reconstituted Solution
Reconstituted solution is stable for 7 days at 2-8°C and for 24
hours at room temperature
MOA:
-
Sulbactam is an irreversible inhibitor of βlactamase; by binding and inhibiting β-lactamase produced by bacterial cells, sulbactam is thereby able to prevent it from reducing antibiotic activity.
INDICATIONS:
-
lower Respiratory Tract Infections (RTI)
-
Bacteremia/Sepsis
-
Meningitis
-
surgical wounds
-
Urinary tract Infections (UTI)
-
Blood Infections
-
Lung infections (Pneumonia)
- Acinetobacter infections - 6g/day TID
- Renal Impairment
| Creatinine Clearance (mL/min)
|
Maximum Dosage
|
| 15-30
|
1gm BID |
|
< 15
|
500mg BID |
Reconstitution :
-
sulbactam is a beta-lactamase inhibitor antibiotic combined with
other antibiotics to treat a variety of susceptible bacterial
infections.