ZAVEPOL (CEFTAZIDIME-AVIBACTAM)
ZAVEPOL (CEFTAZIDIME-AVIBACTAM)
- Ceftazidime pentahydrate eq. to 2 g ceftazidime
- Avibactam sodium eq. to 0.5 g avibactam.
- Reconstitute single-dose vials of ceftazidime /avibactam by adding 10 mL of compatible IV solution (sterile water for injection, 0.9% sodium chloride injection, 5% dextrose injection, 2.5% dextrose and 0.45% sodium chloride injection, lactated Ringer's injection) to the vial; mix gently.
- Volume of reconstituted solution is approximately 12 mL; approximate concentration is ceftazidime 167 mg/mL and avibactam 42 mg/mL.
- Zavepol vial should be stored at 25°C (77°F). Protect from light. Store in carton until time of use.
- The diluted solution in the infusion bags may be stored under refrigeration at 2 to 8°C (36 to 46°F) up to 24 hours following dilution and used within 12 hours of subsequent storage at room temperature.
- Ceftazidime:
3rd generation cephalosporin - Avibactam:
Non-β-lactam β-lactamase
Dilution :
- Prior to IV infusion, reconstituted solutions must be further diluted.
- To prepare indicated dose, withdraw appropriate volume of reconstituted solution from the vial and add to a compatible IV solution to achieve a total final volume of 50–250 mL in an IV infusion bag.
Adults with estimated CrCL > 50 mL/min:
Paediatric patients with estimated CrCL > 50 mL/min:
Route of Administration:
| Type of infection | Dose | Frequency / Infusion Time | Duration of treatment |
|---|---|---|---|
| cIAI | 2 g/0.5 g | Every 8 hours / 2 hrs. | 5-14 days |
| cUTI, including pyelonephritis | 5-10 days | ||
| HAP/VAP | 7-14 days | ||
| Bacteraemia | in accordance with the site of infection | ||
| Gm -ve infections with limited treatment options. | Guided by the severity of the infection |
Route of Administration:
IV/IM
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